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| Structure | ID | Name | POI | Tag Type | Degradation Pathway | Activity | Reference | Year | Details | |
|---|---|---|---|---|---|---|---|---|---|---|
| HyT-001 | Compound 7 | POIEGFR | Tag Typetert-Butyl(diphenyl)silane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50 = 0.75±0.1 μM, DC50 = 1.42±0.3 μM | Reference10.1021/acs.jmedchem.4c02273 | 2024.12.02 | Details | ||
| HyT-002 | TX2-121-1 | POIHER3 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityIC50 = 49.2 nM (LanthaScreen ®technology (Life Technologies) kinase binding assay) | Reference10.1038/nchembio.1658 | 2014.10.19 | Details | ||
| HyT-003 | 12I | POIAkt3EGFR | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50 = 13 nM; DC50 = 578.6 nM; DC50 = 0.007 ± 0.001 μM | Reference10.1021/acs.jmedchem.2c01246 | 2022.09.29 | Details | ||
| HyT-004 | EA-Boc3Arg | POIGSTPGST-α1 | Tag TypeBoc3Arg | PathwayUbiquitin-Independent Proteasome Pathway | ActivityDC50 = 10 μM ; Dmax = nearly complete degradation | Reference10.1016/j.chembiol.2012.04.008 | 2012.05.25 | Details | ||
| HyT-005 | AZ-9 | POICDK9 | Tag TypeS-indacene | PathwayAutophagy-lysosomal Pathway | ActivityGI50 = 0.72 μM ; DC50 = 0.4073 μM; DC50 = 1.215 μM | Reference10.1016/j.apsb.2025.03.047 | 2025.05.14 | Details | ||
| HyT-006 | HyT-9 | POIEML4-ALK | Tag TypeNorbornene | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=134 nM,IC50=0.07±0.01 μM | Reference10.1002/anie.202217246 | 2023.01.20 | Details | ||
| HyT-007 | MIC | POIBSA | Tag Typem-carborane | PathwayUbiquitin-Proteasome Pathway | Activity | Reference10.1021/acs.bioconjchem.1c00431 | 2021.10.26 | Details | ||
| HyT-008 | J26 | POIEML4-ALK | Tag TypeNorbornene | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=0.080 μM;IC50=0.025 μM | Reference10.1021/acs.jmedchem.5c00488 | 2025.07.24 | Details | ||
| HyT-009 | H7 | POIEML4-ALK | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=0.13±0.01 μM;IC50=0.23 ± 0.03 μM | Reference10.1016/j.bioorg.2025.108876 | 2025.08.14 | Details | ||
| HyT-010 | Poloxin-2HT | POIPLK1PLK2PLK3 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=37.5±4.9 μM;IC50=10.5±1.6 μM;IC50=51.9±3.5 μM | Reference10.1002/anie.201809640 | 2018.10.23 | Details | ||
| HyT-011 | Poloxin-2HT+ | POIPLK1PLK2PLK3 | Tag TypeAdamantane | Pathway | ActivityDC50=20.3±3.9 μM;IC50=48.2±4.9 μM;IC50=54.8±11.0 μM;IC50=9.2±0.9 μM | Reference10.1039/c9ob00080a | 2019.03.08 | Details | ||
| HyT-012 | 16a | POIER | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50<1 μM;IC50=0.31±0.04 μM;IC50=0.41±0.12 μM;IC50=0.48±0.11 μM | Reference10.1016/j.ejmech.2021.114081 | 2021.12.29 | Details | ||
| HyT-013 | G-5b | POIER | Tag Type1,1,1,2,2-pentafluoro-5-(propylsulfonyl)pentane | PathwayUbiquitin-Proteasome Pathway | Activity | Reference10.1016/j.ejmech.2023.11593 | 2023.11.08 | Details | ||
| HyT-014 | RA3 | POIER | Tag TypeD-ring-contracted artemisinin | PathwayUbiquitin-Proteasome Pathway | ActivityDC50<10 μM;IC50=2.28 μM | Reference10.1021/acs.jmedchem.4c02269 | 2025.01.03 | Details | ||
| HyT-015 | SARD279 | POIAR | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=1 μM;IC50=156 nM | Reference10.1002/anie.201503720 | 2015.06.17 | Details | ||
| HyT-016 | A9 | POIAR | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50<10 μM;IC50=1.75±0.42 μM;IC50=16.57±1.8 μM; | Reference10.1016/j.ejmech.2020.112512 | 2020.10.15 | Details | ||
| HyT-017 | Compound 13 | POIARAR-V7 | Tag TypeDimethylphenylsilane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=1.9848±0.038 μM;DC50=0.6617±0.014 μM;DC50=1.024±0.025 μM;DC50=0.852±0.01 μM | Reference10.1016/j.ejmech.2026.118617 | 2026.04.05 | Details | ||
| HyT-018 | LL-K9-3 | POICDK9Cyclin-T1ARcMyc | Tag Type(−)-menthoxyacetyl | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=0.662 μM;DC50=0.589 μM;IC50=0.095±0.012 μM | Reference10.1021/acs.jmedchem.2c00257 | 2022.08.04 | Details | ||
| HyT-019 | LL-CDK9-12 | POICDK9Cyclin-T1 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=0.362 μM;DC50=0.683 μM;IC50=169.47±7.16 nM | Reference10.1002/cbdv.20230076 | 2023.06.22 | Details | ||
| HyT-020 | LL-K8-22 | POICDK8Cyclin-C | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=2.52 μM;DC50=2.64 μM;IC50=5.73±0.97 nM;IC50=5.87±0.64 nM;IC50=6.22±0.36 nM | Reference10.1021/acs.jmedchem.2c02045 | 2023.03.17 | Details | ||
| HyT-021 | NH-11 | POINAMPT | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=3.18 μM;DC50=6.05 μM;DC50=7.32 μM;IC50=0.73±0.31 μM;IC50=0.03±0.01 μM;IC50=0.95±0.38 μM | Reference10.1016/j.cclet.2023.109392 | 2023.12.12 | Details | ||
| HyT-022 | R8 | POIGPX4 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=0.019 μM;IC50=0.024 μM;IC50=0.032 μM | Reference10.1016/j.ejmech.2024.116719 | 2024.07.27 | Details | ||
| HyT-023 | N15 | POIGPX4 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=0.028 μM;IC50=3.1 nM； | Reference10.1016/j.ejmech.2025.118269 | 2025.10.14 | Details | ||
| HyT-024 | Z2d | POIPD-L1 | Tag Type4,4′-bifluorobenzhydrylpiperazinyl | PathwayUbiquitin-Proteasome Pathway | Activity | Reference10.1039/d4md00320a | 2024.07.04 | Details | ||
| HyT-025 | Z3d | POIPD-L1 | Tag Type4,4′-bifluorobenzhydrylpiperazinyl | PathwayUbiquitin-Proteasome Pathway | Activity | Reference10.1039/d4md00320a | 2024.07.04 | Details | ||
| HyT-026 | 8E | POIGLI1 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=5.4 μM;IC50=0.462 μM | Reference10.1016/j.bioorg.2023.106649 | 2023.06.07 | Details | ||
| HyT-027 | SKLB-0124 | POIPRMT6 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=15.4 μM;DCmax=64.8 %;DC50=14.6 μM;DCmax=70.4 %;IC50=1616.547 nM;IC50=5.68 μM;IC50=6.66 μM | Reference10.1016/j.bioorg.2024.107439 | 2024.05.10 | Details | ||
| HyT-028 | 1a | POIHDAC1HDAC2HDAC6 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50≈20 μM;IC50=192.3±11.0 nM;IC50=295.0±49.4 nM;IC50=5.2±0.4 nM;IC50=3.97±0.70 μM | Reference10.1021/acsmedchemlett.3c00468 | 2023.11.15 | Details | ||
| HyT-029 | 11E | POIPARP1 | Tag TypeNorbornene | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=2.16±0.29 μM；IC50=4.18±0.30 μM；IC50=11.15 ± 0.18 μM；IC50=6.96 ± 0.12 μ M | Reference10.1016/j.bioorg.2026.109507 | 2026.01.18 | Details | ||
| HyT-030 | 14b | POIα-Tubulinβ-Tubulin | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=5 μM；44 % degradation=5 μM；IC50=0.032±0.01 μM；IC50=0.060±0.02 μM；IC50=0.029±0.02 μM；TGI=74.27 % | Reference10.1016/j.ejmech.2024.116458 | 2024.04.28 | Details | ||
| HyT-031 | Ad-ATRA-1 | POICRABP2 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=1 μM | Reference10.3390/ph13030034 | 2020.02.25 | Details | ||
| HyT-032 | Ad-ATRA-2 | POICRABP2 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50<1 μM | Reference10.3390/ph13030034 | 2020.02.25 | Details | ||
| HyT-033 | Ad-JQ1 | POIBRD3 | Tag TypeAdamantane | Pathway | ActivityDC50<30 μM | Reference10.3390/ph13030034 | 2020.02.25 | Details | ||
| HyT-034 | 14c | POIWRN | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=1.7 μM;DC50=3 μM;DC50=5.9 μM;Dmax=98 %;Dmax=98 %;Dmax=99 %;IC50=2.7±0.3 μM;IC50=0.1 μM;IC50>100 μM. | Reference10.1016/j.ejmech.2025.118121 | 2025.09.04 | Details | ||
| HyT-035 | L12 | POINA | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityEC50=0.68 μM | Reference10.1039/d4nj05067c | 2025.03.06 | Details | ||
| HyT-036 | HyT 3 | POIHTT | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50<10 μM | Reference10.1021/acsmedchemlett.1c00500 | 2022.02.16 | Details | ||
| HyT-037 | CJ1 | POIDAPK1 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=0.1842 μM;IC50>20 μM | Reference10.1016/j.jare.2025.12.037 | 2025.12.27 | Details | ||
| HyT-038 | HyT-Tau-CPP | POITau | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDmax=80%;IC50<150 μM;Kd=0.7655±0.1882 μM | Reference10.1039/c7ra05347a | 2017.08.18 | Details | ||
| HyT-039 | 23 | POIBRD4 | Tag TypeAdamantane | PathwayUPR; Autophagy-lysosomal Pathway | ActivityDC50=24.7 μM;Dmax=57.4 %;IC50=20.6±3.2 μM. | Reference10.1021/acsomega.4c09726 | 2025.01.30 | Details | ||
| HyT-040 | 3a | POIPARP1 | Tag TypeFluorene | PathwayUPR; Ubiquitin-Proteasome Pathway | ActivityDC50<2.5 μM;IC50=2.10±0.31 μM;IC50=5.72±0.44 μM. | Reference10.1016/j.ejmech.2020.112635 | 2020.10.15 | Details | ||
| HyT-041 | 2C | POIPARP1 | Tag Type4-Cyclohexylbuta-1,3-diynylbenzene | PathwayUPR; Autophagy-lysosomal Pathway | ActivityDC50=618 nM;Dmax=55%;IC50=0.062±0.01 μM; | Reference10.1016/j.ejmech.2025.118413 | 2026.02.05 | Details | ||
| HyT-042 | MS1943 | POIEZH2 | Tag TypeAdamantane | PathwayUPR; Ubiquitin-Proteasome Pathway | ActivityGI50=2.2 μM;IC50=0.12 μM | Reference10.1038/S41589-019-0421-4 | 2019.12.09 | Details | ||
| HyT-043 | Fur-Boc3Arg | POIGST-a1 | Tag TypeBoc3Arg | Pathway | ActivityDC50<40 μM | Reference10.1016/j.chembiol.2012.04.008 | 2012.05.25 | Details | ||
| HyT-044 | TMP-Boc3Arg | POIeDHFR | Tag TypeBoc3Arg | PathwayUbiquitin-Independent Proteasome Pathway | ActivityDC50<1.6μM; | Reference10.1016/j.chembiol.2012.04.008 | 2012.05.25 | Details | ||
| HyT-045 | HY8 | POIKRAS | Tag TypeO-carborane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50<50 µM | Reference10.1021/acsbiomedchemau.6c00004 | 2026.03.10 | Details | ||
| HyT-046 | CZY43 | POIHER3 | Tag TypeAdamantane | PathwayAutophagy-lysosomal Pathway | ActivityDC50=0.559 μM;IC50=0.53μM | Reference10.1016/j.ejmech.2025.117258 | 2025.05.15 | Details | ||
| HyT-047 | HyT-S7 | POIHBC | Tag TypeAdamantane | PathwayAutophagy-lysosomal Pathway | ActivityDC50=3 .02± 0.54 μM; EC50=0.46 μM | Reference10.1016/j.apsb.2025.02.033 | 2025.05.08 | Details | ||
| HyT-048 | 7b | POIGPX4 | Tag TypeAdamantane | PathwayAutophagy-lysosomal Pathway; Ubiquitin-Proteasome Pathway | ActivityIC50=0.13±0.006 μM; DC50= 0.057 μM | Reference10.1016/j.bioorg.2024.107115 | 2024.01.16 | Details | ||
| HyT-049 | II-6 | POISIRT2 | Tag TypeBoc1-Trp | PathwayAutophagy-lysosomal Pathway; Ubiquitin-Proteasome Pathway | ActivityIC50=0.002 ±0.001 μM; | Reference10.1016/j.cclet.2025.111143 | 2026.04.15 | Details | ||
| HyT-050 | ADC4EA | POIGSTP | Tag TypeAdamantane | PathwayAutophagy-lysosomal Pathway; Ubiquitin-Proteasome Pathway | ActivityDC50<40 μM; IC50<80 μM | Reference10.1021/acsmedchemlett.0c00627 | 2021.05.13 | Details | ||
| HyT-051 | LPM3770277 | POICDK4CDK6 | Tag TypeAdamantane | PathwayAutophagy-lysosomal Pathway; Ubiquitin-Proteasome Pathway | ActivityIC50=17.73 nM | Reference10.3389/fphar.2022.853993 | 2022.04.11 | Details | ||
| HyT-052 | APL-PLA | POIAR | Tag Typepolylactic acid | PathwayAutophagy-lysosomal Pathway; Ubiquitin-Proteasome Pathway | ActivityDC50=18.25 μM | Reference10.1021/acsnano.4c12747 | 2025.03.04 | Details | ||
| HyT-053 | SMD1 | POIBRD4 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway; Autophagy-lysosomal Pathway | Activity | Reference10.31635/ccschem.023.202302873 | 2023.07.24 | Details | ||
| HyT-054 | 19b | POIPA | Tag TypeBoc₂-(L)-Lys | PathwayAutophagy-lysosomal Pathway; Ubiquitin-Proteasome Pathway | ActivityEC50=0.015±0.001 μM;CC50=97.58 μM;DC50=0.06 μM; | Reference10.1021/acs.jmedchem.4c00131 | 2024.06.13 | Details | ||
| HyT-055 | JQ-HyT | POIBRD4 | Tag TypeAdamantane | Pathway | ActivityIC50=2.25±0.36(37℃)μM;0.59±0.06(45℃)μM | Reference10.1002/smll.202504000 | 2025.06.23 | Details | ||
| HyT-056 | PySAHA | POIHDAC1HDAC2HDAC6 | Tag TypePyrene | Pathway | ActivityIC50=6.20±0.8 μM,2.0±0.9 μM(light irradiation 10 minutes),0.7±0.2 μM(light irradiation 20 minutes);IC50=25.7±4.4 μM;IC50=67.57 nM;TGI =81.2%(PySAHA),108.0%(PySAHA and light irradiation） | Reference10.1039/d5cc01722j | 2025.06.05 | Details | ||
| Hyt-057 | D-4-6 | POIAR | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50<5μM;IC50=4.77 ± 0.26 μM | Reference10.1016/j.bioorg.2024.107309 | 2024.03.26 | Details | ||
| HyT-058 | Nutlin-3a-HT | POIMDM2 | Tag TypeAdamantane | Pathway | ActivityIC50=2.83 ± 0.40μM;IC50=10.5±2.5 μM（48h）,0.83±0.17 μM （120 h）;Ki=1.24±0.18 μM（MDM2） | Reference10.1039/c9cc07795b | 2019.11.05 | Details | ||
| Hyt-059 | 17c | POIPDEδ | Tag TypeAdamantane | Pathway | ActivityIC50=4.8±0.2μM;IC50=7.7±2.0μM;IC50=17.5μM;DC50=11.4 μM;ki=26 nM | Reference10.1021/acsmedchemlett.1c00670 | 2022.01.12 | Details | ||
| Hyt-060 | D4 | POITDP-43 | Tag TypeAdamantane | Pathway | Activity | Reference10.1016/j.bioorg.2018.11.042 | 2018.11.30 | Details | ||
| HyT-061 | AbH6 | POIABL1 | Tag TypeNorbornene | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=185±29 nM;DC50=210 ± 40 nM;GI50=102 ± 3 nM;GI50=107 ± 2 nM;IC50=22±20 nM | Reference10.1002/anie.2319269 | 2026.04.20 | Details | ||
| HyT-062 | NBE5 | POIKEAP1 | Tag TypeNorbornene | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=0.82 μМ;DC50=1.72 μМ;Dmax=82.7%;Dmax=72.2% | Reference10.1016/j.ejmech.2026.118700 | 2026.04.15 | Details | ||
| HyT-063 | HY12 | POIJNK1 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway; Autophagy-lysosomal Pathway | ActivityDC50=0.16 μМ | Reference10.1016/j.bioorg.2026.109756 | 2026.06.15 | Details | ||
| HyT-064 | 7J | POINA | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=0.6366 μМ;Dmax=95 %;EC50=11.13 nМ;EC50=12.55 nM;EC50=12.09 nM;CC50>200 μM | Reference10.1021/acs.jmedchem.5c03547 | 2026.03.12 | Details | ||
| HyT-065 | B2 | POIRET | Tag TypeNorbornene | PathwayUbiquitin-Proteasome Pathway | ActivityDC50<10 μМ | Reference10.1016/j.bmcl.2026.130588 | 2026.02.16 | Details | ||
| HyT-066 | Compound 2 | POILDHAGO | Tag TypeAdamantane | PathwayAutophagy-lysosomal Pathway | ActivityIC50=1.05 μM;IC50=53 nM;Ki=390 nM;Ki=40 nM | Reference10.1021/acs.jmedchem.5c02055 | 2026.02.12 | Details | ||
| HyT-067 | VI-10h | POIERα | Tag TypeL-Boc2Lys | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=1.08 nM;IC50=3.16 nM;EC50=0.82 nM;EC50=0.089 nM | Reference10.1002/ange.202525741 | 2026.05.26 | Details | ||
| HyT-068 | YL2-HyT6 | POISCR-1 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityKi=237 nM;DC50=5 μM | Reference10.3390/ijms22126407 | 2021.06.15 | Details | ||
| HyT-069 | hyt13 | POIHalotag | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityIC50=21 nM | Reference10.1038/nchembio.597 | 2011.07.03 | Details | ||
| HyT-070 | HyT36 | POIHalotag | Tag TypeAdamantane | Pathway | ActivityDC50<10 μM | Reference10.1002/cbic.201100793 | 2011.01.23 | Details | ||
| Hyt-071 | V-2 | POIEGFR | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50< 1 μM | Reference10.1016/j.bmcl.2026.130668 | 2026.05.08 | Details | ||
| Hyt-072 | B-7 | POIALK | Tag TypeNorbornene | Pathway | ActivityIC50=68.98 nM | Reference10.1016/j.bioorg.2026.109674 | 2026.06.05 | Details | ||
| Hyt-073 | B-10 | POIALK | Tag TypeTetraasterane moieties | PathwayUbiquitin-Proteasome Pathway | ActivityIC50=97.77 nM;IC50=1.20 nM | Reference10.1016/j.bioorg.2026.109674 | 2026.06.05 | Details | ||
| Hyt-074 | B3 | POIEGFR | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway; Autophagy-lysosomal Pathway | ActivityDC50=0.61 μM;DC50=0.73 μM;Dmax=80.4 %；Dmax=76.3%；IC50=171 nM;IC50=245 nM | Reference10.1007/s11030-026-11669-1 | 2026.07.16 | Details | ||
| Hyt-075 | SN-38-A2 | POITOP 1 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50<10 nM;IC50=6.2 nM | Reference10.1021/jacs.6c03638 | 2026.04.29 | Details | ||
| Hyt-076 | 20a | POIER | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50<5 μM;DC50<10 μM;IC50=7.727 μM;IC50=21.66±1.87 nM;IC50=4.28±0.61 μM;IC50=1.86±0.33 μM | Reference10.1016/j.bioorg.2026.110129 | 2026.09.15 | Details | ||
| Hyt-077 | 7i | POIPARP1 | Tag Typebicyclo[1.1.1]pentane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=4.31±0.67μM;DC50=5.62 ± 0.41 μ M | Reference10.1016/j.bioorg.2026.110274 | 2026.10.05 | Details | ||
| Hyt-078 | XSY12 | POINSD3 | Tag TypeFluorene | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=2.21±0.37μM;Dmax=80.2%;IC50=0.21±0.03 μM | Reference10.1021/acs.jmedchem.6c00983 | 2026.08.13 | Details | ||
| Hyt-079 | CJ1 | POIDAPK1 | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=0.1842 μM | Reference10.1016/j.jare.2025.12.037 | 2025.12.27 | Details | ||
| HyT-080 | RPV'-N-C2-AmPEG4-Ad | POIRT | Tag TypeAdamantane | PathwayUbiquitin-Proteasome Pathway | ActivityIC50=22.93 µM;IC50=26.62 nM | Reference10.64898/2026.09.24.753933 | 2026.09.25 | Details | ||
| HyT-081 | RS-1 | POIGPX4 | Tag Typediphenylbutan-1-amine | PathwayUbiquitin-Proteasome Pathway | ActivityDC50=8.9±0.2 nM;IC50=130 nM;IC50=6.4μM;IC50=700nM | Reference10.1021/acsomega.5c07348 | 2026.02.02 | Details | ||
| HyT-082 | Q5 | POIHDAC6 | Tag TypeD-ring-contracted artemisinin | PathwayUbiquitin-Proteasome Pathway | ActivityIC50=0.18 μM;DC50=6,357 μM;Dmax=87.31%; | Reference10.1016/j.bioorg.2026.110275 | 2020.10.05 | Details |