Basic Information
Remarks
Chemical Identifiers
Basic Properties
Lipinski RO5
Hydrophobic Tag Properties
Mechanism of Action
POI (Protein of Interest)
Amino Acid Sequence
3D Structure (/structures/AF-P08263-F1-model_v6.cif)
Function
Glutathione S-transferase that catalyzes the nucleophilic attack of the sulfur atom of glutathione on the electrophilic groups of a wide range of exogenous and endogenous compounds (Probable). Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2). It also catalyzes the isomerization of D5-androstene-3,17-dione (AD) into D4-androstene-3,17-dione and may therefore play an important role in hormone biosynthesis. Through its glutathione-dependent peroxidase activity toward the fatty acid hydroperoxide (13S)-hydroperoxy-(9Z,11E)-octadecadienoate/13-HPODE it is also involved in the metabolism of oxidized linoleic acid.
Degradation Pathway
Activity Data
Description
Fur-Boc3Arg-modified GST-α1 was readily degraded in lysates from NIH 3T3 cells （Figure 1F）. (F) Degradation of GST-α1 by Fur-Boc3Arg. Purified C-terminally HA-tagged GST-α1 was modified with Fur-Boc3Arg (40 μM) and added to NIH 3T3 cell lysates supplemented with an ATP regenerating system.
Disease Information
| Disease | ICD-11 | Source |
|---|---|---|
| Hemorrhagic Cystitis | GC00.1 | Gene-Disease Association |
| Hepatic Veno-Occlusive Disease | DB98.6 | Gene-Disease Association |
| metabolic disease | 5D2Z | Gene-Disease Association |