We are pleased to announce the first public release of HyTdb, a curated knowledge base dedicated to hydrophobic tagging (HyT) degraders — a rapidly growing branch of targeted protein degradation (TPD) research.

What is included

Every compound record in HyTdb is decomposed into its three functional components and linked to experimental evidence:

  • Molecular structure, warhead, linker and hydrophobic tag (with SMILES and ClogP)
  • Protein of interest (POI), UniProt ID, gene and amino acid sequence
  • Degradation pathway and degradation activity (DC50 / IC50 with assay method and cell line)
  • Pharmacokinetic (PK) parameters and disease associations
  • Literature reference (DOI) and publication year

Key features

The platform supports keyword and SMILES search, hydrophobic tag type search, degradation pathway search, and a full structure editor for exact, substructure and similarity queries. A dedicated Browse page allows multi-dimensional filtering by tag type, pathway, POI and publication year, with live counts for each filter value.

All data can be exported in bulk as a structured table (CSV) and a structure file (SDF) — from the homepage, the Browse page, or any individual compound detail page.

Data model

Each compound detail page presents basic information, chemical identifiers, computed physicochemical properties with a Lipinski RO5 radar chart, a dedicated hydrophobic tag properties panel, mechanism of action (POI, degradation pathway, activity data, PK), and disease information.

Availability

HyTdb is available as an open web resource. Bulk datasets can be obtained from the Download page. We welcome corrections and new entries through the online feedback form on the Help page.

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